It just depends on your personal preference I find that they work best pared with our dryer balls. Depending on how much fabric softener you currently use will determine your need for something additional like dryer balls or the static eliminator sheets.
The Ecoballs do not replace fabric softener they replace detergent. They replace detergent by adding an ionic charge to the water, the Ecoballs bind the water to contaminants and wash them away.